Biocompatibility evaluation of PET artificial ligament coating hydroxyapatite by fibroblasts cells in vitro
Hydroxyapatite (HA)-based materials have been widely used in the field of ligament tissue engineering in the past decades.It has been previously reported that HA can increase the penetration of marrow-derived mesenchymal stem cells (MSCs) and MSCs cells into scaffolds due to increased cell differentiation in biological media.Additionally,it was found that there are much difference between MSCs and anterior cruciate ligament (ACL) cells.For that reason,we mainly evaluate the biocompatibility of PET-silk scaffold with fibroblasts cells in vitro.We cultured BALB/C CL7 mouse fibroblasts cells on the substrate of PET fiber and PET-HA scaffold,respectively,and then observed the morphology by using scanning electron microscopy.Our data indicate that PET-HA scaffold has good biocompatibility with fibroblasts cells and can potentially be useful in enhancing the fibroblasts cell differentiation and proliferation.
Artificial ligament ligamentization hydroxyapatite fibroblasts cell biocompatibility
Jia Jiang Wei Hao Yuzhuo Li Jun Chen Jinrong Yao Zhengzhong Shao Hong Li Jianjun Yang Shiyi Chen
Fudan University Sports Medicine Center & Department of Sports Medicine and Arthroscopy Surgery,Huas Laboratory of Advanced Materials, National Key Laboratory of Molecular Engineering of Polymers,Depar Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication Te
国际会议
上海
英文
188-188
2012-10-19（万方平台首次上网日期，不代表论文的发表时间）