Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels
This study was to prepare polycaprolactone (PCL) nanoparticles.The biodegradable PCL was used as the carrier,and Azithromycin (AZM) was used as the model drug.AZM-PCL nanoparticles (AZM-PCL-NPS) were prepared by desolvation method.The effect of preparation condition:concentration of PCL,molecular weight of PCL,organic solvents,dosage ratio and so on,were specially noted and compared.A homogeneous size distribution and good dispersion were observed,the average diameter was around 70~400 nm,and the distribution index was 0.036~0.136.The drug loading reached 27.69 %,and the efficiency of encapsulation reached as high as 93.25%.The results were better than the other similar researches,this preparation way was successful.
AZM-PCL Nanoparticels Desolvation Method Property of Drug Loading
Lili Ruan Daxin Wang Youwei Zhang Jiongxin Zhao Minwu Wang Xiufang Zhang Nanliang Chen
College of Materials Science and Engineering, Donghua University, Shanghai, 201620,China Yangzhou University Medical Academy, Yangzhou, 225001, China Key Laboratory of Textile Science &Technology Ministry of Education, Donghua University,Shanghai, 20
国际会议
台湾
英文
1764-1768
2011-12-11（万方平台首次上网日期，不代表论文的发表时间）