Freeze Drying Technology Forming Drug Release Bionic Scaffolds with Gradient Structure
A kind of drug release bionic scaffold with gradient structure was designed to release drugs.The scaffold mould had been designed with CAD software and fabricated with rapid prototype.The bionic beta-tricalcium phosphate (β-TCP) scaffold was fabricated with freeze drying.It was composed of two coaxial cylindrical porous scaffolds.The internal loose scaffold was embedded in the outer dense layer.The two different density layers of the scaffold could be used to adjust the drug releasing rate through regulating the slurry concentration.The scaffold was distributed with pores ranged from 30μm to 100μm.The research indicated that the scaffold with gradient structure could be loaded with two kinds of drugs which were released at different rate.The scaffolds were fit as the substitute materials for bone repairing.
Freeze drying Drug release Beta-tricalcium phosphate Gradient structure
Liulan Lin Liping Zhou Zhikun Wang Qingxi Hu Minglun Fang
School of Mechatronics Engineering and Automation, Shanghai University, 200444, China
国际会议
台湾
英文
3935-3939
2011-12-11（万方平台首次上网日期，不代表论文的发表时间）