Biomimic Enamel Remineralization by Hybridization Calcium-and Phosphate-Loaded Liposomes with Amelogenin-Inspired Peptide
We here report a novel biomimetic mineralization strategy for enamel remineralization by intergration of calcium phosphate loaded and thermally triggered liposomes and a self-assembly amelogenin-inspired peptide.Firstly,calcium and phosphate loaded temperature sensitive liposomes were synthesized by lnterdigitation-fusion method with 1,2-bis(palmitoyl)-sn-glycero-3-phosphorcholine (DPPC) and 1,2-bis(myristoyl)-sn-glycero-3-phosphocholine (DMPC) at mass ratio of 9∶1.The liposomes were stable at room temperature,but slowly released calcium and phosphate ions if heated to 37 ℃.Secondly,a novel polyanion amelogenin-inspired oligopeptide (Gln-Pro-Ala)4-Thr-Lys-Arg-Glu-Glu-Val-Asp) was synthesized by standard solid-phase.Finally,the mixture of peptide and liposomes solution was exposed to enamel surface at 37 ℃.The results showed oriented enamel-like hydroxylapatite evenly deposited on enamel surface.
Enamel Biomimetic mineralization Temperature-sensitive liposomes Amelogenin Self-assembly
Jingjing Luo Tianyun Ning Ying Cao Xiaopeng Zhu Xiaohua Xu Xuyan Tang Chun Hung Chu Quanli Li
Key Lab.of Oral Disease Research of Anhui Province,College of Stomatology,Anhui Medical University,H Faculty of Dentistry,The University of Hong Kong,Hong Kong,China
国际会议
The Seventh China International Conference on High-Performance Ceramics (第七届先进陶瓷国际研讨会(CICC-7))
厦门
英文
1727-1730
2011-11-04（万方平台首次上网日期，不代表论文的发表时间）