Preparation of Mineralized Electrospun PCL/Gelatin Scaffolds via Double Diffusion System

摘要：

　　For successful reconstruction of skeletal defects,a range of materials including ceramics,polymers and their composites have been developed.The goal of our work is to prepare mineralized PCL/gelatin composite scaffolds in a double diffusion system as implants for bone tissue engineering application.Fibrous PCL/gelatin scaffold fabricated via electrospinning followed by immersing into disodium-β-glycerophosphate(β-GP) (10 mg/ml) for 12h were used as substrates for calcium phosphate (CaP) mineralization.The precipitation reaction was biomimetically carried out in a double diffusion system for a week.The CaP minerals precipitated on the scaffold were characterized by X-ray powder diffraction,Fourier transform infrared spectroscopy,scanning electron microscopy and high-resolution transmission electron microscopy.The results show that apatite aggregates are combination of HAP,DCPD and ACP.β-GP can effectively promote the formation of CaP crystals.The composite scaffold fabricated in this paper hold promise for use in bone tissue engineering.

关键词： Electrospinning Biomineralization Glycerophosphate Tissue engineering

作者: Zhenzhao Guo Hong Li Weicheng Guan Bo Xue Changren Zhou

作者单位: Department of Material Science and Engineering,College of Science and Engineering,Jinan University,Guangzhou 510632 China

会议类型: 国际会议

会议名称: The Seventh China International Conference on High-Performance Ceramics (第七届先进陶瓷国际研讨会(CICC-7))

会议地点: 厦门

会议语种:英文

页码: 1740-1745

在线出版日期: 2011-11-04（万方平台首次上网日期，不代表论文的发表时间）