Preparation and Properties of Injectable Hydroxyapatite for Bone Repair Materials
The aim of this study was to develop a novel injectable hydroxyapatite for bone repair materials.This study was based on the in situ setting properties of calcium phosphate cement (CPC),which properties were improved.The solid phase consisted of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA).The liquid phase was the weak acidic solution of chitosan.The CPC powder was mixed with the chitosan solution to form a paste that could conform to the bone cavity even for irregularly shaped cavities.All the by-production disappeared by neutralization reaction.The CPC paste could then set in situ to form hydroxyapatite (HA) as the final product.The chemical process of CPC hydration was studied.The process was controlled by dissolution and precipitation chemical reaction.The kinetic model of hydration reaction was established.The effects of preparing conditions,such as powder to liquid ratio and particle size,on setting time and compressive strength were investigated systematically.The optimal condition was that the liquid phase contained 3% chitosan,5% citric acid and 15% glucose (wt%),powder to liquid ratio was 0.8 g/ml,and powders were respectively ground for 40 hours.
injectable hydroxyapatite bone repair materials chitosan
Hua Liu Xiaofeng Chen Changren Zhou
College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640 College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640 Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
国际会议
The Sixth China International Conference on High-Performance Ceramics(第六届中国先进陶瓷国际研讨会(CICC-6))
哈尔滨
英文
590-593
2009-08-16（万方平台首次上网日期，不代表论文的发表时间）