Preparation of Porous Polycaprolactone Scaffolds by using Freeze-drying Combined Porogen-leaching Methods

摘要：

　　The microstructure of scaffold was one of key factors for tissue engineering.Porous polycaprolactone (PCL) scaffolds were fabricated by combination ofporogen-leaching and freeze-drying process.Ice particulates were used as porogen material,and PCL solutions in chloroform were mixed with ice particulates for 5minuture at zero temperature.Then the mixture was freezed in liquid nitrogen,and porous scaffold was prepared by freeze-drying finally.The microstructure and properties of the scaffolds were investigated.Porous structure of the scaffolds showed that good 3D microstructure and no porogen remained in the scaffold; pore size and porosity were determined by the size and mass fraction of ice particulates.The results demonstrated that the Scaffolds possessed open and interconnected pores with sizes ranging from several μm to more than 300μm and porosities of 50~80%.

关键词： Pore size Scaffold Polycaprolactone

作者: Chengyun Ning Haimei Cheng Zhaoyi Yin Wenjun Zhu Hao Chen Shumei Lei Shiheng Yin Huaguo Liu

作者单位: College of Materials Science and Technology,South China University of Technology,Guangzhou 510641,Ch College of Materials Science and Technology,South China University of Technology,Guangzhou 510641,Ch Guanghua School of Stomatology,Sun Yat-sen University,Guangzhou 510060,China Wenzhou Medical College,Wenzhou 325035,China College of Materials Science and Technology,South China University of Technology,Guangzhou 510641,Ch

会议类型: 国际会议

会议名称: The Fifth China International Conference on High-Performance Ceramics (第五届先进陶瓷国际研讨会(CICC-5))

会议地点: 长沙

会议语种:英文

页码: 1224-1226

在线出版日期: 2007-05-10（万方平台首次上网日期，不代表论文的发表时间）