Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate
Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility,biological degradability,and porosity.This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold.In this study,critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP.The resulting grafts were examined by X-ray,histological examination,semi-quantitative analysis of osteogenesis,immunochemical examination (collagen type Ⅰ and Ⅲ),scanning electron microscopy and transmission electron microscopy.The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.
Tissue engineering Bone marrow stromal cells Hydroxyapatite-tricalcium phosphate
Lei Liu Runliang Chen Yunfeng Lin Weidong Tian Shengwei Li
West China College of Stomatology,Sichuan University,Chengdu 610041,P.R.China Department of Stomatology,First Peoples Hospital of Tianjin,Tianjin 300192,P.R.China
国际会议
The Fifth China International Conference on High-Performance Ceramics (第五届先进陶瓷国际研讨会(CICC-5))
长沙
英文
1235-1237
2007-05-10（万方平台首次上网日期，不代表论文的发表时间）