Immunomodulatory effects of carbon dots to the normal BALB/c mice
Evaluation of the immunomodulatory potentials of nanomaterials is essential for developing safe and consumer-friendly nanotechnology.However,few studies have concentrated on the immunotoxicity of carbon dots.Here we investigated the effect of carbon dots on the normal balb/c mice immune system.The mice were treated with different dosages of carbon dots and normal saline.After intravenous administration of carbon dots for 9 days,the proliferation,subpopulation of the peripheral lymphocytes and the induction of primary immune responses in mice were investigated.The results showed that the organ coefficients of spleen and thymus were not different between the experimental groups and control group (P>0.05).The proliferation of splenocytes has a significant increase in the 50 mg/kg group when compared to the control group (P < 0.05).In peripheral lymphocytes,both the proportions of subset CD4+ and CD8+ T lymphocytes in carbon dots treated groups were higher than those in the control group,whereas there was no difference in the number of CD4+ and CD8+ T cells between the administration groups.Furthermore,the Carbon dots markedly enhanced the production of interferon-γ (IFN-γ) in peripheral lymphocytes.It is concluded that Carbon dots could influence immune functions of the normal balb/c mice by inducing the Th1 cell response.
Zhongcai Gao Guangxia Shen Xiu-nan Zhao Na Dong Qian Lee Junhua Wu Daxiang Cui Yingge Zhang Yu-xia Wang
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing100850, China National Key Laboratory of Nano/Micro Fabrication Technology, Research Institute of Micro/Nano Scien
国际会议
中国微米纳米技术学会第14届学术年会、第3届国际年会暨第6届微米纳米技术“创新与产业化国际研讨与展览会(CSMNT2012 & ICMAN2012)
杭州
英文
1-4
2012-11-04（万方平台首次上网日期，不代表论文的发表时间）