An Interstitial Fluid Transdermal Extraction Chip with Vacuum Generator and Volume Sensor for Continuous Glucose Monitoring

摘要：

　　A five layer microfluidic chip which is designed and fabricated for interstitial fluid (ISF) transdermal extraction,collection,and measurement toward the application of continuous and real-time glucose monitoring is presented in this paper.The microfluidic chip consists of a Venturi tube generating vacuum for ISF extraction and fluid manipulation,a novel volume sensor of electrolytic fluid for normal saline input volume control and ISF volume measurement,pneumatic valves for fluid management,and access ports for glucose sensor integration.The output vacuum of the Venturi tube is tested,and a less than 88kPa vacuum has been achieved,when 220kPa external pressure is applied.The feasibility of using the volume sensor to control and measure the normal saline input volume is confirmed by high accuracy and low coefficient of variation (CV=0.0040,n=12).The microfluidic chip is ready for glucose sensor integration in continuous glucose monitoring.

关键词： continuous glucose monitoring interstitial fluid, microfluidic chip volume sensor

作者: Haixia Yu Dachao Li Yongjie Ji Xiaoli Zhang Kexin Xu

作者单位: State Key Lab of Precision Measuring Technology and Instruments, Tianjin University, Tianjin, China

会议类型: 国际会议

会议名称: 中国微米纳米技术学会第14届学术年会、第3届国际年会暨第6届微米纳米技术“创新与产业化国际研讨与展览会(CSMNT2012 & ICMAN2012)

会议地点: 杭州

会议语种:英文

页码: 1-5

在线出版日期: 2012-11-04（万方平台首次上网日期，不代表论文的发表时间）