Development of a Biomedical Micro/Nano Robot for Drug Delivery

摘要：

　　Flagellated bacteria have been utilized as potential swimming micro-robotic bodies for propulsion of spherical liposome by attaching several bacteria on their surface.Liposome as a drug delivery vehicle can contain biologically active compounds.In this work,the antibody binding technique is developed to attach bacteria to liposome’s surface.Consequently,the stochastic effect of bacterial propulsion of liposome is investigated analytically and experimentally.It is shown that the mobility of liposome with bacteria was higher than that of liposome without bacteria.Experimental data matches well with statistical calculation.

关键词： micro/nano robot bacterial flagellar motor liposome antibody Drug delivery system

作者: Zhenhai Zhang Zhifei Li Kejie Li

作者单位: School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China Department of General Surgery, Peking University Third Hospital, Beijing 100191, China

会议类型: 国际会议

会议名称: 中国微米纳米技术学会第14届学术年会、第3届国际年会暨第6届微米纳米技术“创新与产业化国际研讨与展览会(CSMNT2012 & ICMAN2012)

会议地点: 杭州

会议语种:英文

页码: 1-7

在线出版日期: 2012-11-04（万方平台首次上网日期，不代表论文的发表时间）