Fabrication of organic-inorganic hybrid nanopore and its application in biosensing
Nanopore and nanopore based bio-sensing technology have become into more and more interesting research area in the past ten years.In this work,micro-pore in Si-S3N4 chips was fabricated and characterized by Focused Ion Beam (dual Beam),and then the S3N4 pore was covered by Polycarbonate (PC) membrane containing 50nm nanopores and sealed by using polydimethylsiloxane (PDMS) to get hybrid micro-nanopores.The obtained chip with hybrid nanopores together with two liquid cells was integrated into an ionic current detection device for biosensing.Based on this device,λ-DNA in the electrolytic solution can be detected when it is electrophoretically driven through the hybrid nanopores,and different gestures of λ-DNA in translocation also can be discriminated.
Nanopore sensing DNA
Lei Liu Zhaowen Cai Yaozong Hou Bing Wang Chao Dai Zhonghua Ni Yunfei Chen
Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments,School of Mechanics, Southeast University, Nanjing 210096, Peoples Republic of China
国际会议
中国微米纳米技术学会第14届学术年会、第3届国际年会暨第6届微米纳米技术“创新与产业化国际研讨与展览会(CSMNT2012 & ICMAN2012)
杭州
英文
1-6
2012-11-04（万方平台首次上网日期，不代表论文的发表时间）