SimulationSimulations and Experimental Studies on Biomolecules Passing through Polycarbonate Nanopore Arrays

摘要：

　　Nanopore and nanopore based biosensing and DNA sequencing have attracted more and more interests in the past ten years.In this paper,a simplified model is addressed to depict biomolecules passing through nanopores arrays.Based on this model,the passing velocity of biomolecules will not increase continuously but first increase,then decrease and stabilize with the IgG concentration increasing.Due to the physical place-holding effects and the simulation results,it can be predicted that,with biomolecules concentration increasing,the ionic current will first decrease,then increase and finnally stabilize.These predictions based on the simulation match our experimental results well.

关键词： Nanopore biosensing simulation

作者: Lei Liu Chao Dai Bing Wang Zhaowen Cai Zhonghua Ni Yunfei Chen

作者单位: Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments,School of Mechanics, Southeast University, Nanjing 210096, Peoples Republic of China

会议类型: 国际会议

会议名称: 中国微米纳米技术学会第14届学术年会、第3届国际年会暨第6届微米纳米技术“创新与产业化国际研讨与展览会(CSMNT2012 & ICMAN2012)

会议地点: 杭州

会议语种:英文

页码: 1-6

在线出版日期: 2012-11-04（万方平台首次上网日期，不代表论文的发表时间）