The Function of CdSe/ZnS,CdTe/ZnTe Nanoparticles in Caco-2, MDCK and MDCK-MDR1 Cells

摘要：

　　Aim: To investigate the function of CdSe/ZnS and CdTe/ZnTe nanoparticles through Caco-2,MDCK and MDCK-MDR1 cell monolayers.Methods: Using enterocyte-like Caco-2 cells as a small intestine epithelial model,Madin–Darby canine kidney (MDCK) and MDCK-MDR1 cell(overexpressed P-gp) as blood-brain barrier (BBB), permeability of CdSe/ZnS and CdTe/ZnTe quantum dot (QD) across monolayers based on these cells were quantified with fluorescence using a spectral scanning multimode reader (Varioskan Flash version 2.4.3,Thermo Scientific,America).P-gp was inhibited using Cyclosporin A.Toxicology of these nanoparticles was also studied by MTT.

关键词： Caco-2 cells MDCK cells MDCK-MDR1 cells permeability quantum dot nanoparticle

作者: Peiyuan Jia Zheng Li JunhuaWu Na Dong Zhongcai Gao Qian Li YuxiaWang

作者单位: Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850,China

会议类型: 国际会议

会议名称: 中国微米纳米技术学会第14届学术年会、第3届国际年会暨第6届微米纳米技术“创新与产业化国际研讨与展览会(CSMNT2012 & ICMAN2012)

会议地点: 杭州

会议语种:英文

页码: 1-3

在线出版日期: 2012-11-04（万方平台首次上网日期，不代表论文的发表时间）