In Vitro Antibacterial Properties of Vancomycin-loaded Nano-hydroxyapatite/Collagen/ Calcium Sulfate Hemihydrates (VCM/nHAC/CSH) Bone Substitute
In the present study,a new antibacterial bone graft substitute has been developed for repairing bone defects and inhibiting related infections at the same time.Calcium sulphate hemihydrate (CSH) was introduced into nano-hydroxyapatite/collagen (nHAC) to prepare a self-setting in situ bone repair materials.The nHAC/CSH was used as a carrier of vancomycin (VCM) for anti-infection and the treatment of osteomyelitis.The VCM/nHAC/CSH composite was a porous scaffold with porosity of 38.8% and the compressive mechanical strength was about 4.8 MPa.The final setting time was about 15~20 min.The inhibition ratio of VCM/nHAC/CSH was more than 99.8% and the distinct inhibition zone of 18 mm was formed in Staphylococcus aureus bacterium incubation dish with VCM/nHAC/CSH disc in the center of agar matrix for 16 hours of incubation.After incubating 17 days at 37℃ in vitro,the concentration of vancomycin in elution fluild was around 12 μg/mL.Therefore,the VCM/nHAC/CSH bone substitute presents ideal self-setting antibacterial,cytocompatibility,sustained release properties and has great potential applications for the treatment of bone defect-related infection in orthopedic surgeries.
Bone substitute Antibacterial Nano-hydroxyapatite/collagen/ calcium sulfate hemihydrates, Vancomycin Biocompatibility
Xiaojie Lian Xiumei Wang Fuzhai Cui
Key Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
国际会议
the Chinese Materials Congress 2012(2012年中国材料大会(CMC2012))
太原
英文
6-12
2012-07-13（万方平台首次上网日期，不代表论文的发表时间）