In Vitro and in Vivo Studies on a Mg-Li-X Alloy System Developed as a New Kind of Biological Metal
Magnesium alloys have a good application prospect in the fields of bone implants and cardiovascular stents due to their excellent properties,such as close density and elastic modulus to those of nature bone,high specific strength and rigidity,biodegradation and biocompatibility.In this paper,the feasibility of the use of the forged Mg-Li-X alloys (Mg-Li-Al-Zn-Ca-Sr) as biodegradable metals was investigated by immersion tests in the Hank’s solution and skin-tissue implantation tests.The methods of SEM-EDS and XRD were used to research the corrosion morphology and corrosion products of the forged Mg-Li-X alloys after the in-vitro and in-vivo tests.At last,the in-vitro cytotoxicity was investigated by the MTT tests on L929 cells.Results showed that corrosion mechanism of the forged Mg-Li alloys was pitting and the surfaces were covered by Mg(OH)2,CaCO3 and Ca(H2PO4)2.During the 5 weeks implantation period,the rats survived from the operation,which indicates that the elements and the compounds formed are non-toxic to the rats.The forged Mg-Li alloy showed Grade 0~1 cytotoxicity,which manifests the forged Mg-Li alloy has good biocompatibility and eligible toxicity for implant applications.
Magnesium alloys Corrosion Biodegradability Biocompatibility
Sha Luo Qingqing Zhang Yanchang Zhang Chao Li Xiaoqing Xu Tietao Zhou
School of Mat. Sci. & Eng., Beihang University, Beijing 100191, China Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China School of chemical sciences, Inner Mongolia Normal University, Huhhot 010000, China
国际会议
the Chinese Materials Congress 2012(2012年中国材料大会(CMC2012))
太原
英文
257-263
2012-07-13（万方平台首次上网日期，不代表论文的发表时间）