Study on in Vitro Degradation of Sutures for Decomposable Esophageal Stent

摘要：

　　PLLA and PGLA sutures for decomposable esophageal stent were investigated in phosphate buffer solution (PBS) (pH=7.4) at 37℃ for period of 8 weeks.The in vitro degradation was studied by determining the change of weight loss,pH value,intrinsic viscosity,tensile strength,orientation degree,degree of crystallinity,melting point and surface morphology of the suture samples.The results showed that all properties of PLLA sutures had no obvious changes,however,the properties of PGLA sutures all changed significantly.The pH value,intrinsic viscosity,tensile strength,orientation degree and degree of crystallinity decreased gradually,and the weight loss of PGLA sutures increased with the degradation time.At 6th week,tensile strength of PGLA sutures nearly reached zero,and weight loss approached to 70% at 8th week.The results of DSC showed that melting point of crystalline region of PGLA sutures substantially remained unchanged and melting heat enthalpy increased gradually during in vitro degradation,and the new ordered regions appeared in the amorphous area.The results of SEM showed that surface coating of PGLA sutures spalled initially,and then the sutures occured transverse rupture.Therefore PGLA suture is suitable to prepare decomposable esophageal stent to expand benign esophageal stenosis or stricture,but stent prepared by PLLA suture is not appropriate for treatment of benign esophageal stenosis because it is decomposed for more than 2 months.

关键词： PLLA PGLA suture in vitro degradation decomposable esophageal stent

作者: WANG Qin LIU Ji-Yong WANG Chuan-Dong MA Li-Xia LIU Yang LI Jun-Qi LIU Jin

作者单位: Shandong Institute of Medical Instruments, Shandong Provincial Key Laboratory of Biomedical Polymers Shandong Provincial hospital, Jinan, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 59-62

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）