会议专题

Preparation of Chitosan/Poly(L-Lactide) Porous Composite Scaffolds

  This research investigated the formation of chitosan/poly(L-lactide) (CS/PLLA) porous composite scaffold using a novel emulsion freeze-drying technique.First,an oilin- water (O/W) emulsification system was used in the presence of surfactant Tween-80,in which CS solution was used as the water phase and PLLA solution was used as the oil phase.The emulsion was observed by inverted microscope (×200).The emulsion droplet was spherical and uniform in size.FT-IR analysis revealed that there were hydrogen bonding interactions between CS and PLLA components.The microstructure and physical properties of the scaffolds were also analyzed.The SEM results showed that composite scaffolds formed well interconnected pore structure and homogenous distribution of CS and PLLA.When the content of PLLA reached 50% the porosity of CS/PLLA composite scaffolds were between 83~91% and density in the range of 0.047 to 0.11 g/cm3.The porosity showed a slight decrease and the density increased with increasing PLLA dose.The compressive strength increased from 0.32 to 0.43 MPa,while the compressive modulus increased from 1.99 to 3.91 MPa as the PLLA contents increased from 10% to 50%.

Biomaterials chitosan poly(L-lactide) emulsion composite

Pin Chen Xufeng Niu Zhending She Gang Zhou Rongwei Tan Jiangxue Wang Yubo Fan

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Sc Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Sc Key Laboratory of Biomedical Materials and Implants, Research Institute of Tsinghua University in Sh

国际会议

World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

北京

英文

83-86

2012-05-26(万方平台首次上网日期,不代表论文的发表时间)