STUDY ON THE PREPARATION AND PERFORMANCE OF CROSS-LINKED HYALURONIC ACID RELEASE CARRIER

摘要：

　　Hyaluronan (HA) is a kind of suitable drug carrier,but HA in polar medium is not stable.In this paper,in ethanol (non-polar),the toxicity and degradability of cross-linked HA derivatives with STMP and DVS were researched,to prepare cross-linked HA microspheres by ultrasonic emulsification.The results demonstrated that HA-STMP products had better biocompatibility and resistance to degradation,the morphology of HA-STMP microspheres was better,the particle size distribution of microspheres was 50nm-lOum.Therefore,the best preparation circuit is optimized,HA-STMP nano-microspheres of ideal drug carrier have been prepared successfully.

关键词： Hyaluronan Cross-Iink Microsphere Toxicity Degradability

作者: X. Liu G.Y. Hui H.Q. Gu

作者单位: Biomedical Engineering Laboratory,Tianjin Institute of Urological Surgery, Tianjin, China Department of Biomedical Engineering, Tianjin Medical University, Tianjin, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 121-124

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）