Trichostatin A and Shear Stress in Regulating Endothelium Differentiation of Bone Marrow Mesenchymal Stem Cells

摘要：

　　Differentiation of bone marrow mesenchymal stem cells (MSCs) into endothelial cells (EC) is characterized by the expression of specific endothelial marker genes.Mechanical stimulations play potential effects in EC oriented differentiation of MSCs.However,molecular mechanisms of endothelial differentiation from MSCs have not been defined.Histone acetylations play important roles in regulating gene expression.Histone acetylation status is maintained by histone acetyltransferase (HAT) and histone deacetylases (HDACs).Our previous work described that VEGF and laminar shear stress (SS) work together in determining EC oriented differentiation of MSC.Trichostatin A (TSA) is one of the histone deacetylase inhibitor.In this study,we found that both TSA and SS could induce EC oriented differentiation of MSCs.And TSA combined with SS showed more powerful influence on the EC oriented differentiation of MSCs.

关键词： bone marrow mesenchymal stem cells endothelial cells differentiation shear stress Trichostatin A

作者: Wei Song Yan Huang XiaoLing Jia XiangHui Gong LiSha Zhen YuBo Fan

作者单位: Key Lab for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 196-198

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）