The in vivo 3D Optic nerve head modeling based on human multimodality images
Introduction: The Human Optic Nerve Head (ONH) is vulnerable to damage in glaucomatous high intraocular pressure (IOP).In order to analyze the human ONH head stress and deformation in high IOP,an in vivo three dimensional (3D) ONH model was reconstructed by optical coherence tomography (OCT) images and Magnetic Resonance Imaging (MRI) images.Materials and Methods: A human eye was scanned by MRI and OCT in serial imaging protocol.The sclera and ONH were segmented from the images,and 3D models were reconstructed by multimodality image registration.Through the Morphological segmentation,part of lamina cribrosa (LC) was acquired and reconstructed in combination with the ONH and sclera.Results: The models of ONH and sclera were got,the part of LC was included in the model.In the analysis of FEM,the ONH was compressed and the cup/disk ratio was changed obviously in high glaucomatous IOP.Discussion: This study described a method to build a 3D in vivo ONH model by image processing.It can be used in biomechanical analysis,and provide the stress state of ONH for the research about the fundus damage of glaucoma.
Glaucoma Optic nerve head Multimodality image Finite element analysis Biomechanics
Jianfeng Qiu Xiuqing Qian Haiying Quan Wangjun Zhicheng Liu
School of Biomedical Engineering, Capital Medical University, Beijing 100069, China;Department of Ra School of Biomedical Engineering, Capital Medical University, Beijing 100069, China Department of Radiology, The fourth peoples hospital, Taian, Shandong 271016, China
国际会议
World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))
北京
英文
264-266
2012-05-26（万方平台首次上网日期，不代表论文的发表时间）