Silicon Nanowire-Based Methodology for Quantifying Single Cell Traction Force

摘要：

　　In this paper,we present a new method,a siliconnanowire- array based technique for quantifying the mechanical behavior of single cells,representing three distinct groups: normal mammalian cells,benign cells (L929) and malignant cells (HeLa).By culturing the cells on top of NW arrays,the maximum traction forces of different cells have been measured by quantitatively analyzing the bending of the nanowires.The elastic modulus of the as-fabricated Si-NW arrays was first measured before cell culturing.Finite Element (FEM) simulations were carried out in order to derive the relationship between the applied transverse force and the corresponding tip displacement for a Si-NW.Our study is likely important for studying the mechanical properties of single cells and their migration characteristics,possibly providing a new cellular level diagnostic technique.

关键词： Silicon Nanowire Array Cell Traction Force Finite Element Simulation Cellular Mechanical Properties

作者: Y.S. Niu L. Yan M. Dai X. Li S.Y. Feng F. Xue Y.B. Fan Z. Li

作者单位: School of Biological Science and Medical Engineering, Beihang University, Beijing, China;Key Lab for School of Biological Science and Medical Engineering, Beihang University, Beijing, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 282-285

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）