Dispersion of Dynamic Biochemical Signals in Steady Flow in a Shallow Y-type Microfluidic Channel
This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel.A method is presented to control the flow widths of two steady flows in the Y-type microchannel from two inlets.The transfer function for the Y-type microchannel is given by solving the governing equation for the Taylor-Aris dispersion in the microchannel.The amplitude-frequency and phase-frequency relations are provided which show that a shallow Y-type microchannel acts as a low-pass filter.The transports of different dynamic biochemical signals are investigated.In comparison with a fully mixing microfluidic channel,the magnitudes of the dynamic signals at the outlets in a Ytype microchannel are much smaller than those in a fully mixing microchannel,which demonstrates that the amplitude attenuation in a Y-type microchannel is larger than that of a fully mixing microchannel due to the transverse molecular diffusion.In order to control the desired signal in a microchannel,the solution of the inverse problem for the channel is also presented.
Dynamic biochemical signal Shallow Y-type microfluidic channel Steady flow Taylor-Aris dispersion Transfer function
Yong-Jiang Li Yizeng Li Tun Cao Kai-Rong Qin
Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, China Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI. 48109 USA
国际会议
World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))
北京
英文
301-304
2012-05-26（万方平台首次上网日期，不代表论文的发表时间）