A novel synthetic analogue of curcumin,B7,inhibits inflammatory factors expression in H2O2 induced endothelial cells

摘要：

　　Curcumin,a dietary phytochemical,exhibits multifunctional natural product with regulatory effects on inflammation.However,its poor bioavailability limits its clinical applications.Thus,we designed and synthesized a novel monocarbonyl analogue of curcumin B7 and their inhibition against monocyte chemotactic protein-1 (MCP-1) and Interleukin-8 (IL-8) release was evaluated in H2O2-stimulated human vascular endothelial cells (ECs) in a dose-responsive manner,while exhibiting no cytotoxicity in ECs.Taken together,these insights on the novel compound B7 may serve as potential agents for the treatment of atherosclerosis.

关键词： Curcumin Atherosclerosis B7 Inflammation Interleukin-8

作者: Dangheng Wei Yanghui Liu Xiaoying Jia Fengxia Guo Jiangzhang Wu

作者单位: The Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Uni School of Pharmacy, Wenzhou Medical College, 1210 University Town, Wenzhou, Zhejiang 325035

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 636-638

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）