Effect of Galanin on the Axonal Guidance Growth after Shear Stress in the Cultured Cortical Neurons

摘要：

　　Traumatic brain injury (TBI) is serious problems for health.Traffic accident and high shear stress induced head injury.But the certain mechanism is not clear yet.Here we investigated that the effect of galanin on the injured cortical neurons after shear stress.Our results showed that shear stress at 10 dyn/cm2 for 4 h induced marked neuronal injury,but galanin can regulate the mRNA level of RHO signal pathway and inhibit shear stress induced injury by RT-PCR assay.Our study suggested that the galanin may protect against injury through promoting axonal guidance growth after shear stress in TBI.

关键词： Shear stress Rat cortical neurons Netrinl Galanin RHO signal pathway

作者: Rulong Zhang Jianqiang Wen Meili Liu Yubo Fan

作者单位: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Sci Institute of Acoustics. The Chinese Academy of Sciences, Beijing 100190, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 647-650

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）