Lipoprotein(a) inhibits EPCs neovascularization of hindlimb ischemia tissues in rabbit

摘要：

　　Increased level of lipoprotein(a)Lp(a) had been identified as an independent risk factor for coronary and peripheral blood disease.Here,we studied the impact of Lp(a) (20μg/ml) on endothelial progenitor cells (EPCs) and determined whether Lp(a) affected EPCs by an inhibitory effect on its neovascularization,as it had cleared that EPCs involved the incorporation of postnatal neovascularization.EPCs were isolated from mouse bone marrow and cultured by differential attachment method.In vivo,we demonstrated that Lp(a) inhibited EPCs migration and homing to sites of ischemic tissues and reduced the number of neogenetic micrangium markedly,neovascularization was inhibited.

关键词： endothelial progenitor cells Lipoprotein(a) neovascularization bone marrow ischemia

作者: Ren Wang Zhi-sheng Jiang Zuo Wang Shuang Li Kai Zhang Jian Yang Guo-hua Li Xiao-long Lin Xiao-feng Ma Jian-jun Lei Yue Zhao

作者单位: Institute of Cardiovascular Research, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001,China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 668-671

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）