Study on Cerebral Infarction in Rat Brain with Diffusional Kurtosis Imaging
Diffusional kurtosis imaging (DKI) is increasingly used to characterize the degree to which water in biological structure diffuses in a non-Gaussian behavior.Because non- Gaussian behavior represents tissue complexity,DKI can be employed to measure tissue’s microstructure.The purpose of this study is to investigate the feasibility of DKI in cerebral infarction on rat models,and further explore the clinical diagnosis value in aspects of revealing stroke lesions and classifying cerebral infarction of different stages quantitatively.Using 9 different b-values (0,400-3200 s/mm2),non-Gaussian kurtosis (yielding both apparent diffusion coefficient Dapp and apparent kurtosis coefficient Kapp) fits were performed on a voxel-byvoxel basis.Ischemia tissues present a relatively high signal on mean kurtosis (MK) map.MK map shows more pathological information of cerebral infarction than apparent diffusion coefficient (ADC) map.rMK (rMK = lesion MK value/ the contralateral part MK value) values evolve regularly in different stages of infarct,which may help in clinical diagnosis.
magnetic resonance imaging diffusional kurtosis imaging (DKI) cerebral infarction apparent diffusion coefficient (ADC) mean kurtosis (MK)
ST. Suo YH. Li YZ. Chen YM. Zhu S. Zhang
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai, China CREATIS, CNRS UMR 5220, INSERM U1044, INSA of Lyon and University of Lyon, Villeurbanne, France
国际会议
World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))
北京
英文
995-998
2012-05-26（万方平台首次上网日期，不代表论文的发表时间）