A novel approach to intra-operative planning for prostate brachytherapy

摘要：

　　This paper presents an efficient and stable algorithm to intra-operative planning for prostate brachytherapy.As a heuristic approach,the algorithm selects one seed at a step and iterates until predefined prostate volume is covered by prescribed dose.For each step,potential seeds are evaluated according to the ability to irradiate target while spare adjacent organs at risk.And its influence on dose homogeneity is also taken into account.Furthermore,a flexible mechanism is adopted to limit the number of used needles.The mechanism selects acceptable sub-optimal seed in existing needles instead of optimal seed that requires adding a new needle.The efficacy of the algorithm is evaluated on five clinical patient cases.Compared with state-of-the-art methods,this algorithm is efficient,stable and without the trial and error process of determining various parameters.These advantages make the algorithm suitable for intra-operative real-time treatment planning.

关键词： prostate brachytherapy optimization intraoperative planning

作者: Liang Bin Liu Bo Zhou Fugen Wang Junjie Xu Yong

作者单位: Image Processing Center, Beihang University, Beijing, China The Center of Oncology, Peking University Third Hospital, Beijing, China Department of Urology, the General Hospital of PLA, Beijing, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 1853-1856

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）