A Finite Element Model Revealing Stress Distribution on Tissue Engineering Scaffold in Perfused Bioreactor

摘要：

　　It has been well reported that the mechanical stimuli altered the physiological behaviors of cells and mediated the tissue engineering scaffold degradation.However,the accurate local stress was still unknown inside the scaffold since the microstructure is too complicated to study using traditional methods.In this study,we developed a simplified finite element model to evaluate the stress range and distribution on the porous scaffold in perfused bioreactor.Due to our results,the stress on scaffold decreased from inlet to outlet under perfusing while increased under drawing;the stress distribution range on scaffold was closely correlated with the flow rate and scaffold permeability.In conclusion,our study suggests that lower flow rate and higher scaffold permeability generated more uniform mechanical environment for cell growth and scaffold degradation.

关键词： Scaffold finite element bioreactor flow rate permeability

作者: J. Fan X. Y. Liu Y. B. Fan

作者单位: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering,Beihang University, Beijing, China

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 1984-1986

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）