Negative-Feedback Regulation of ATP Release During Ischemia in Cardiac Myocytes

摘要：

　　Extracellular ATP acts as a potent agonist on cardiomyocytes,inducing a broad range of physiological responses via P2 purinoceptors.Its concentration in the interstitial space within the heart is elevated during ischemia or hypoxia due to its release from a number of cell types,including cardiomyocytes.However,the exact mechanism responsible for the release of ATP from cardiomyocytes during ischemia is not known.In this study,we investigated whether and how the release of ATP was strictly regulated during ischemia in cultured neonatal rat cardiomyocytes.Here we show the possibility that the release of ATP from cardiomyocytes was strictly regulated during ischemia by negative-feedback mechanisms; that is,maxi-anion channel-derived ATP-induced suppression of ATP release via hemichannels in cardiomyocytes.

关键词： maxi-anion channel purinoceptor hemichannels negative-feedback ATP release cardiomyocyte

作者: Koichi Kawahara Satohiko Kunugi Sadahiro Iwabuchi Daisuke Matsuyama

作者单位: Laboratory of Cellular Cybernetics Graduate School of Information Sci. & Technol., Hokkaido University

会议类型: 国际会议

会议名称: World Congress on Medical Physics and Biomedical Engineering (2012年医学物理及生物医学工程国际会议(IFMBE))

会议地点: 北京

会议语种:英文

页码: 2196-2199

在线出版日期: 2012-05-26（万方平台首次上网日期，不代表论文的发表时间）