From the Topological View to Explain Why False Hub is not Essential
Centrality-lethality rule demonstrates that proteins with high degree in the protein-protein interaction (PPI) network are more likely to be essential than those selected by chance. Nevertheless, in PPI network, there are still many proteins with high degree are not essential (false hubs). Comparing the difference between false hubs and essential hubs from topological perspective, such as centrality measures, damage, clustering coefficient and interactions between neighbors, there are distinguishable significant properties of false hubs. False hubs have lower subgraph centrality and less interactions between neighbors, which could explain why they are not essential in some extent.
false hub essential hub protein-protein interaction network centrality measure clustering coefficient
DONG Yun-yuan YANG Jun LIU Qi-jun WANG Zheng-hua
College of Computer, National University of Defense Technology, Changsha, China No.91 Element of 92941 Troops of the Chinese Peoples Liberation Army, Huludao, China College of Science, National University of Defense Technology, Changsha, China
国际会议
杭州
英文
81-84
2012-10-28（万方平台首次上网日期，不代表论文的发表时间）