Cation-anionicpalladium Complexes - New Types of Antitumor, Immune Response-modulating and Radioprotective Agents

摘要：

Here we report results of our investigations of new class of bioactive palladium compounds (Ahn)mPdCl4, which were discovered as a result of systematic study of correlations between composition, structure and bioactivity of different types of platinum metals coordination compounds. For the first time we demonstrated in vivoa possibility of development of palladium compounds, which exceed cisplatin in antitumor activity and do not show immunosuppressive effects, and palladium compounds with immunostimulating and radioprotective activities. Combinations of cytostatic agents or radiation with palladium complexes lead to significant synergism of their activities and high therapeutic efficiency exceeded an efficiency of their separated use.

关键词： palladium chlorides heterocyclic amines antitumor agents immune response-modulating agents radioprotective agents

作者: EFIMENKO I. A SHISHILOV O. N IVANOVAN. A EROFEEVAO. S

作者单位: N.S. Kurnakov Institute of General and Inorganic Chemistry of RAS, Moscow, Russia

会议类型: 国际会议

会议名称: 5th International Conference Platinium Metals(第五届国际贵金属会议)

会议地点: 昆明

会议语种:英文

页码: 240-242

在线出版日期: 2012-10-15（万方平台首次上网日期，不代表论文的发表时间）