Determination of Residues and Safety Analysis of Metal Impurities in Platinum-based Antitumor Drugs

摘要：

The residual metal impurities in cisplatin, carboplatin and oxaliplatin were determined by ICP-AES.The samples were ignited and dissolved with HC1:HNO3 (3:1). The method is simple and accurate. By the determination of the metal residues in the samples, the calculated actual daily exposure and concentration of the metal Pd, Ir, Rh, Ru, Mo, Ni, Cr, V, Cu, Mn, Fe and Zn that were less than the permitted daily exposures (PDE) and the limited concentration permitted in the EMEA guideline on the specification limits for residues of metal catalysts or metal reagents . The metal residues can de adequately removed from the active pharmaceutical ingredients and the corresponding drugs. The trace metal residues will not affect human health and lead to the safety hazard by the intravenous injection.

关键词： ICP-AES platinum-based antitumor drug metal reagent residue safety

作者: PENG Juan PU Shaoping LI Guangli HE Jian ZHANG Zhirong LIAO Yunxing

作者单位: Guiyan Phamaceuitical Co, Ltd., Kunming 650106, China Guiyan Phamaceuitical Co, Ltd., Kunming 650106, China Kunming University of Science and Technology, Sino-Platinum Metals Co. Ltd., Kunming 650106, China

会议类型: 国际会议

会议名称: 5th International Conference Platinium Metals(第五届国际贵金属会议)

会议地点: 昆明

会议语种:英文

页码: 258-262

在线出版日期: 2012-10-15（万方平台首次上网日期，不代表论文的发表时间）