Improved Synthesis of MIriplatin
Miriplatin, a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma. An improvd synthetic route was designed and used to prepare the target compound. The intermediate Pt(C6H14N2)(I)2 was synthesized from K2PtCl4, KI and (1R,2R)-1,2-cyclohexanediamine, Pt(C6H14N2)(I)2 was reacted with AgNO3 to prepare Pt(C6H14N2)(H2O)2(NO3)2 solution then was subsequently reacted with CH3(CH2)12COONa in n-butanol to give target compound with satisfied yield 81％(based on Pt(C6H14N2)12). The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, 1H-NMR, thermal analysis, the structure was consistent with the target compound.
antitumor drug miriplatin improved synthesis
WANG Qingkun PU Shaoping LIU Zhudong, LIU Liangmeng LIAO Yunxing JIN Ji
Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug, Kunming Guiyan Pharmaceutical Co. Ltd., Kunming 650106, China
国际会议
5th International Conference Platinium Metals(第五届国际贵金属会议)
昆明
英文
281-283
2012-10-15（万方平台首次上网日期，不代表论文的发表时间）