New Approach to Harmonized Guidelines for Endocrine Disrupter Testing and Assessment
A variety of chemicals including pesticides and their metabolites have been suspected of exerting adverse effects on humans and/or wild life based on their endocrine activities since an endocrine disrupter issue arose in the last decade of the 20th century. Typical examples are organochlorine pesticides such as DDT, DDE and methoxychlor. Suspected adverse effects of endocrine disrupters diverge widely; thus regulators and health advocates are seriously concerned for developmental and reproductive toxicities, immunotoxicity, neurotoxicity and/or carcinogenicity of these pesticides based on their estrogenic and/or antiandrogenic properties.
estrogenic anti-androgenic tiered approach screening assay definitive test
Hiroaki Aoyama
Toxicology Division, Institute of Environmental Toxicology, Joso, Japan
国际会议
北京
英文
41
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）