Harmonized Approach to Future Toxicology Testing for Pesticide Regulation

摘要：

There are 4 major view points to guarantee safety of pesticides: (1) Phyto-toxicity, (2) Operator∏s health, (3) Consumer ∏ s health, and (4) Ecotoxicity. In order to minimize risk on human health from unexpected exposure, a huge volume of toxicological should be prepared through various toxicity studies. Acute toxicity studies via oral/dermal/inhalation routes, eye/dermal irritation studies, and dermal sensitization studies are mainly focused on Point 2. For the Point 3, sub-chronic and chronic repeated oral toxicity studies, reproduction toxicity studies, and carcinogenicity studies are designed to evaluate toxicity for lifespan, transplacental and multi-generation exposure. Genotoxicity data helps to interpret the carcinogenity is primary or secondary.

关键词： toxicity studies harmonization GLPs test guidelines

作者: Kosei Inui

作者单位: Central Research Institute, Ishihara Sagyo Kaisha, Ltd. , Kusatsu, Japan

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 49

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）