Studies on Metabolism and Disposition of Pesticides in Mammals by the Combined in vivo /vitro/silico Assessment Method
In this study, an attempt is made to use a metabolism study as an accurate method to evaluate human risk by in vivo /vitro/silico combination assessment methods. They include the identification of small amounts of metabolites by nuclear magnetic resonance or mass spectrometry in addition to traditional in vivo metabolism study, in vitro metabolism study with cytochrome P450 (CYP) expressed in the microsome or tissue fraction, and in silico prediction of the characteristics of pesticides by physiologically-based pharmacokinetics (PBPK) modeling. The metabolism and characteristics of flufenpyr-ethyl, procymidone, furametpyr, and pyridalyl in animals were analyzed by these methods.
metabolism pesticides cytochrome P450 UDP-glucuronosyltransferase PBPK model
Hirohisa Nagahori
Environmental Health Science Laboratory, Sumitomo Chemical Co. , Ltd. , Osaka, Japan
国际会议
北京
英文
168-169
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）