Rate Pulmonary Proteome and Protein Networks in Response to the Herbicide Paraquat

摘要：

Paraquat (1, 1-dimethyl-4,4-bispyridinium dichloride) (PQ) has been one of the most widely used herbicides worldwide since its introduction in 1962. PQ, when ingested, is very toxic to mammals including humans and may cause acute respiratory distress syndrome. PQ accumulates in the human lungs at a concentration 10 times greater than that in the other tissues. It has been reported that PQ induces pulmonary fibrosis in humans and rats. No successful treatment has passed clinical trials although many treatment protocols for PQ poisoning have been studied.

关键词： paraquat pesticide exposure herbicide shotgun proteomics p53 signaling pathway

作者: Qingxiao Li Ilkyu Cho Mihye Jeong Aresun You Kyunghun Park

作者单位: Department of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96822, US Department of Crop Life Safety, Rural Development Administration, Gyeonggi-do, 441-707, Korea

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 171-172

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）