Development of an Integrated Computational Application and Workflow to Assess the Toxicity Potentials of Chemicals

摘要：

Mammalian hazard characterization is an important component in the product life cycle of organic chemicals, starting from discovery to commercialization and to product stewardship. Significant resources and testing efforts will be needed to meet the regulatory evaluation and risk prioritization of large volume of chemicals. Some examples of the current global regulatory initiatives are the USEPA HPV (High Production Volume Chemicals), Canada DSL (Domestic Substance List) and EU REACH (Registration, Evaluation and Authorization of Chemicals), etc. Under the REACH directive, the use of non-testing data for estimation and assessment of the hazards and risks of a chemical is acceptable as technical alternative.

关键词： prediction in silico technology toxicity mode of actions chemical properties

作者: Philip Lee Feixiong Cheng Yun Tang H.Kaneko

作者单位: School of Pharmacy, East China University of Science and Technology, Shanghai, China Sumika Technical Information Services, Osaka, Japan

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 174

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）