Fatal Incidence of Humidifier Disinfectants in Korea in 2011: Implications for Risk Management of Biocides of Inhalatory Concern
The Korean Center for Disease Control and Prevention (KCDC) announced on August 31, 2011 that the unidentified fatal lung disease found in Korea might have been caused by chemical disinfectants used with household humidifiers. The impact of the chemical incidence was appalling to the society due to its human fatality by abrupt discovery of the symptom and almost rare recovery by medical treatment. Based on the epidemiological investigation that active ingredients of disinfecting products caused this disease, a subchronic 90-day rat inhalation toxicity testing was conducted with 3 commercial disinfecting products which had been found to be the most commonly consumed ones by the patients and families. By November of 2011, the KCDC and concerned experts concluded that the histopathological readings of human patients, bronchiolar fibrosis, and the ones of rats which inhaled products with polyalkylguanidine moiety are identical and The KCDC ordered recalling all the products containing guanidine moiety.
disinfectant humidifier risk assessment inhalation route pulmonary fibrosis
Yong-Hwa Kim
Korea Institute of Toxicology, 141 Gajeong-ro, Youseong-gu,Daejeon, 305-343, Republic of Korea
国际会议
北京
英文
175-176
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）