The Discovery of Insecticidal l-(3,5-Dichloro- pyridin-2-y1) -pyrazole Carboxamides

摘要：

Chlorantraniliprole, as a ryanodine receptor activator, is the first anthranilamide insecticide developed by DuPont. Chlorantraniliprole is characterized by its excellent insecticidal activity, broad pest spectrum across numerous crops and low toxicity to mammals. Based on Chlorantraniliprole s structure, a lead optimization project focusing on the modification of pyridine ring was carried out in our group since 2006. The l-(3, 5-dichloropyridin-2-yl)-pyrazole carboxamide HBY-625 with high insecticidal activity was discovered in 2008. Further optimization on the benzene ring leads to the discovery of compound HBY682.

关键词： ryanodine receptor activator anthranilamide insecticide l-(3, 5-dichloropyridin-2-yl)-pyrazole carboxamide rice leaf folder

作者: Bin Li Huibin Yang Haibo Yu Junfeng Wang Yuquan Song

作者单位: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co Ltd, Shenyang, China

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 293

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）