Design, Synthesis and Fungicidal Activity of Pyrazolecarboxamide Compounds
Tolfenpyrad, a commercialized Pyrazolecarboxamide Derivatives, shows good insecticidal/acaricidal activity against Lepidoptera, Hemiptera, Thysanoptera and eriophyid mites in vegetables, ornamentals and fruit, also active against the fungus Sphaerotheca fuliginea. By using the intermediate derivatization method, an important intermediate (4-(pyridin-2yloxy) phenyl) alkylamines were synthesized starting from (un) substituted 2-halopyridine and phenols containing cyano such as 4-hydroxybenzonitrile, 2-( 4-hydroxyphenyl) acetonitrile and 3-( 4-hydroxyphenyl ) propanenitrile, to replace the corresponding part of Tolfenpyrad. A series of Pyrazolecarboxamide Derivatives were synthesized and bioassayed. The structure-activity relationships of the synthesized compounds were also discussed.
pyrazolecarboxamide compounds intermediate derivatization method synthesis fungicides
Lizeng Wang Changling Liu Xufeng Sun Jie Lan Qin Sun Jinbo Zhang
State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd. , Shenyang, China
国际会议
北京
英文
308
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）