Design, Synthesis and Fungicidal Activity of Glycosylthiadiazole Derivertives as Novel GlmS Inhibitors

摘要：

Glucosamine-6-phosphate synthase ( L-glutamine: Dfructose-6-phosphate aminotransferase (GlmS, 1 EC 2. 6. 1. 16)) catalyzes the first step in hexosamine biosynthesis, converting D-fructose 6-phosphate (Fru6-P) into D-glucosamine 6-phosphate (GlcN-6-P) using glutamine as the ammonia source. GlcN-6-P is a precursor of uridine diphospho-N-acetylglucosamine from which other amino sugar-containing molecules are derived. One of these products, N-acetylglucosamine, is an important constituent of the peptidoglycan layer of bacterial cell walls and fungal cell wall chitin. Accordingly, GlmS offers a potential target for antibacterial and antifungal agents.

关键词： glucosamine-6-phosphate synthase inhibitor glycosylthiadiazole deriverti-ves synthesis fungicidal activity

作者: Jianjun Zhang Shuhui Jin Xiaojing Yan Xiaomei Liang Huizhu Yuan Daoquan Wang

作者单位: Department of Applied Chemistry, China Agricultural University, Beijing, China Chinese Academy of Agricultural Science, Beijing, China

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 335-336

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）