Design, Synthesis and Anti-fungal Activity of the Oleanic Acid Oxime Esters and Oxime Ethers
Glucosamine-6 phosphate synthase (GlmS) is the first enzyme of the hexosamine biosynthetic pathway. As a checkpoint of UDP-GlcNAc synthesis, it plays a key role for the bacterial peptidoglycan, the lipopolysaccharide of Gram-negative bacteria, chitin, and mannoproteins of the fungal cell wall. This enzyme catalyzes the reaction of D-fructose-6P with glutamine to afford D-glucosamine-6P and glutamate. It is irreversible reaction and the sole biosynthetic route to GlcN6P known to date. Although the enzyme is also present in mammalian systems, substantial difference in physiological consequences of GlmS inhibition in fungi and in mammals, constitute a firm molecular basis for the selective toxicity of specific enzyme inhibitors. Recently, this enzyme has been proposed as a good and promising target for new antifungal agents.
oleanolic acid oxime ester oxime ether fungicides
Hanqing Zhao Minjie Zhou Jianjun Zhang Daoquan Wang Xiaomei Liang Yanhong Dong
Key Lab of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100193,China
国际会议
北京
英文
337-338
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）