Docking Interaction Study on Commercial Tyrosinase Inhibitors and Tyrosinase

摘要：

Tyrosinase is the key enzyme in melanin biosynthesis, which affects developmental and defensive functions of insects. The current commercial tyrosinase inhibitors (such as kojic acid, arbutin and azelaic acid) have no common frameworks. Understanding the interaction mode between these inhibitors and tyrosinase is very useful to screen the novel inhibitors. So, in the present study, the molecular docking was employed to analyze the interaction features using the Surflex-dock method in SYBYL7. 3 software.

关键词： tyrosinase tyrosinase inhibitor molecular docking

作者: Xueke Liu Yan Xu Yun Ling Xinling Yang Li Zhang

作者单位: PMDD Lab. , Department of Applied Chemistry,College of Science China Agricultural University, Beijing 100193, China

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 356

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）