Novel Analogues of (E) -β-Farnesene with Potential Control Properties to Myzus persicae (Sulzer)
(E)-β-Farnesene is an effective alarm pheromone in many aphid species. 1,2 It can reduce the use of insecticides at the same level of efficacy by increasing contact of aphids with the toxicant. 3 However, it is prevented in agriculture applications by its susceptibility to oxidation.4 In a programme to develop novel chemicals for aphid control, we have designed and synthesized twelve novel analogues of (E)-β-farnesene, containing a pyrazole moiety present in several insecticides. Binding affinities to three odorant-binding proteins (OBPs) of pea aphid Acythosiphon pisum (Harris) and the repellent activities were evaluated, as well as the aphicidal properties against peach aphid Myzus persicae (Sulzer). Among the chemicals, 3h and 3j, exhibited marked selectivity to OBP3 and displayed significant repellency against M. Persicae, possessing similar repellent activity to the lead, (E)-β-farnesene, but higher stability. While 3a and 3f showed comparable aphicidal activities to (E)-β-farnesene at the same concentration of 0. 6 mg/mL. This work demonstrates that novel analogues of (E)-β-farnesene can be detected as alarm messages, and endowed with repellent activities, as well as insecticidal properties against M. Persicae, which may be new potential aphid control agents.
(E)-β-farnesene analogues odorant-binding proteins repellency insecticidal aphids
Yufeng Sun Yongjun Zhang Shaoxiang Yang Yun Ling Changhui Rui Paolo Pelosi Xinling Yang
PMDD Lab. ,Department of Applied Chemistry, College of Science, China Agricultural University, Key L State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Department of Biology of Agricultural Plants, University of Pisa,via S. Michele 4, 56124 Pisa, Ital
国际会议
北京
英文
368-369
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）