Design of Novel Molting Hormone Agonists/Antagonists

摘要：

Insects grow by repetitively molting, a process that is regulated by a molting hormone, 20hydroxyecdysone (20E) , acting on the ecdysone receptor (EcR). Compounds that are antagonists of 20E binding to EcR are therefore candidates for insecticides. Among them, diacylhydrazine (DAH)-type compounds that mimic the action of 20E have been developed to control insect populations, and several DAHs (tebufenozide, methoxyfenozide, halofenozide, fufenozide, and chromafenozide) are in regular agricultural use worldwide. Most of these DAHs are potent only against Lepidoptera, and not against other insect orders, while halofenozide is used not only for Lepidoptera but also for the Coleptera pests.

关键词： In silico screening molting ecdysone diacylhydrazine ponasterone

作者: Yoshiaki Nakagawa

作者单位: Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 379

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）