Combinatorial Synthesis of 2-Acyloxycycloh- exylsulfonamides and Evaluation of Their Fungicidal Activity
In order to discover fungicides having novel structures, we adopted the method of combining the traditional synthesis with fast mixture library synthesis the research on the structure optimization and the structure-activity relationship of the 2Acyloxycyclohexy-lsulfonamides. Acyl chloride ( 1, R1 ) was reacted with N-substituted phenyl-2hydroxycycloalkylsulfonamides(2, R2) in dichloromethane under the catalysis of TMEDA and molecular sieve to synthesize N-substituted phenyl-2- acyloxycyclohexylsulfonamides (3). The structure optimization of R1 : 13 N-( 2-trifluoromethyl-4chlorinephenyl )-2-acyloxycyclohexylsulfonamides were synthesized which structures were confirmed by 1 H NMR, IR and elemental analyses.
2-acyloxycycloalkylsulfonamides combinatorial chemistry Botrytis cinerea fungicidal activity structure-activity relationship
Xinghai Li Xiaoyuan Chen Qiang Pan Decai Wu Zhiqiu Qi Mingshan Ji
Plant Protection College, Shenyang Agricultural University, Shenyang, China
国际会议
北京
英文
386-387
2012-09-15（万方平台首次上网日期，不代表论文的发表时间）