γ-Aminobutyric Acid Receptors: Multiple Potential Sites for Insecticidal Actions

摘要：

The γ-aminobutyric acid (GABA) receptor, a member of the Cys-loop ligand-gated ion channel family, mediates inhibitory synaptic neurotransmission in the nervous system. The binding of GABA to the receptor enhances chloride ion permeability through its intrinsic channel, thereby suppressing neuronal excitation. While the insect GABA receptor is a validated target of widely used insecticides, it still remains an important target for further development of insecticides, given the presence of multiple binding sites for a variety of compounds.

关键词： γ-Aminobutyric acid GABA receptor channel target of insecticides

作者: Yoshihisa Ozoe

作者单位: Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane 690-8504, Japan

会议类型: 国际会议

会议名称: Proceedings of 4th Internatioanl Symposium on Pesticides and Environmental Safety & 5th Pan Pacific Conference on Pesticide Science & 8th International Workshop on Crop Protection Chemistry and Regulatory Harmonization (四届农药与环境安全会)

会议地点: 北京

会议语种:英文

页码: 396

在线出版日期: 2012-09-15（万方平台首次上网日期，不代表论文的发表时间）