A powerful parent-of-origin effects test for qualitative traits incorporating control children in nuclear families
Genomic imprinting is an important epigenetic phenomenon in studying complex traits and has generally been examined by detecting parent-of-origin effects of alleles. The parental-asymmetry test based on nuclear families with both parents and its extensions to deal with missing parental genotypes are simple and powerful for such a task. However, these methods only use case (affected) children in nuclear families and thus do not make full use of information on control (unaffected) children, if available, in these families. In this article, we propose a novel parent-of-origin effects test C-PATu by using both the control and case children in nuclear families with one or both parents. C-PATu is essentially a weighted framework, in which the test based on all the control children and their parents and that based on all the case children and their parents are weighted according to the population disease prevalence. Simulation results demonstrate that the proposed tests control the size well under no parent-of-origin effects and using additional information from control children improves the power of the tests under the imprinting alternative. Application of C-PATu to a Framingham Heart Study dataset further shows the advantage of C-PATu.
WeiGao Mao HaiQiang He Yan Xu JiYuan Zhou
Department of Biostatistics,School of Public Health and Tropical Medicine,Southern Medical Universit Department of Biostatistics,School of Public Health and Tropical Medicine,Southern Medical Universit Department of Biostatistics,School of Public Health and Tropical Medicine, Southern Medical Universi
国际会议
Second Joint Biostatistics Symposium(第二届生物统计国际研讨会2012)
北京
英文
232-233
2012-07-08（万方平台首次上网日期，不代表论文的发表时间）